European journal of medicinal chemistry 125 2017 255e268 intermediates 19aeg were subsequently removed by treatment with concentrated hcl to give brominated analogues 20aeg. In this work, we aim to study whether sirt3 could serve as a target structure in the design of substrate based pseudopeptidic inhibitors of sirt1 and sirt2. Journal of drug design and medicinal chemistry science. Issues 2020 volume 26, chemistry a european journal. Meooc ome ome ome hooc ohc ome ome ome x ome ome ome 6 x coome 7 xch2oh.
Derivation and validation of toxicophores for mutagenicity. The backbone of the nterminal domain comprises of eightstranded bsheets, atpbinding site which is formed by four ahelices and the overall structural con. European journal of medicinal chemistry 2017, 140, 119. European journal of medicinal chemistry 46 2011 2091e2101. Imination and amidation of sulfides, sulfoxides, and olefins using 4h. Most downloaded european journal of medicinal chemistry. Department of medicinal chemistry, china pharmaceutical university, 24 tongjia xiang, nanjing 29 p. European journal of medicinal chemistry 101 201 5 367 e 383. Articles should describe original research of high quality and timeliness. Data availability statements should include information on where data supporting the results reported in the article can be found, including, where applicable, hyperlinks to publicly archived datasets analysed or generated during the study. If you switch to a different device, you may be asked to login again with only your acs id.
This is one of the privileged scaffolds in medicinal chemistry due to its chemical and metabolic stability and lipophilicity. Youve supercharged your research process with acs and mendeley. Original papers are full papers describing original research of high scientific level and timeliness. European journal of medicinal chemistry vol 183, 1. Received 26 october 2009 received in revised form 30 april 2010 accepted 8 may 2010 available online 15 may 2010 keywords. We created a binding hypothesis for pseudopeptidic inhibitors, synthesized a series of inhibitors, and studied how well the. A typical paper would report on the organic synthesis, characterization and pharmacological evaluation of compounds. European journal of medicinal chemistry 45 2010 4403e4408 determine the concentration of the compound that induces 50% growth inhibition ic 50 of the human cervix epitheloid carcinoma. Most downloaded european journal of medicinal chemistry articles the most downloaded articles from european journal of medicinal chemistry in the last 90 days. Volume 167 pages 1594 1 april 2019 download full issue. European journal of medicinal chemistry 115 2016 381e392. European journal of medicinal chemistry 92 2015 766e775 767. European journal of medicinal chemistry 115 2016 381e392 methylchromones 5a5c. European journal of medicinal chemistry vol 167, pages 1.
European journal of medicinal chemistry 149 2018 69e78 primaquine, 1 fig. The european journal of medicinal chemistry publishes studies on all aspects of medicinal chemistry. European journal of medicinal chemistry 90 2015 448e461 449 4tri. Thus, fap has been considered as a potential target for the diagnosis and therapy of numerous carcinomas. European journal of medicinal chemistry 127 2017 200e209 201. The journal publishes significant research on various. The essential medicinal chemistry of curcumin journal of. International journal of medicinal chemistry hindawi. European journal of medicinal chemistry 62 20 40e50. Structurebased design of pseudopeptidic inhibitors for.
Structureguided design of potent and permeable inhibitors of mers coronavirus 3cl protease that utilize a piperidine moiety as a novel design element. Stilbenes 43,5dimethoxystyrylaniline ht29 xenograft colon cancer abstract. European journal of medicinal chemistry 2017 15e25 17 d opioid receptors were. Doxorubicin dox is a wellknown broadspectrum chemotherapeutic drug. European journal of medicinal chemistry 81 2014 158e175 159 the change of the phenyl moiety to cyclohexyl on amido part of the piperidino and imidazolo derivatives 9, 10, 33, 34 reduced. European journal of medicinal chemistry article pdf available in european journal of medicinal chemistry 102. Development of small molecule inhibitors targeting nlrp3 inflammasome pathway for inflammatory diseases 1 january 2020. The journal encourages authors to provide a statement of data availability in their article.
Research outcomes from medical sciencescase study and biotechnology of pharmaceutical and organic chemistry including synthesis, bioorganic, medicinal. Request pdf on sep 12, 2015, atul d jain and others published european journal of medicinal chemistry find, read and cite all the research you need on researchgate. Data availability statements should include information on where data supporting the results reported in the article can be found, including, where applicable, hyperlinks to publicly. Toxic properties can often be related to chemical structure, more specifically, to particular substructures, which are generally identified as toxicophores. Unlimited viewing of the articlechapter pdf and any associated. European journal of medicinal chemistry 7 2017 196e210 197.
Resources in yunnan, yunnan university, kunming, 650091, p. Curcumin has recently been classified as both a pains panassay interference compounds and an imps invalid metabolic panaceas candidate. European journal of medicinal chemistry 94 2015 23 7 e 251 240 table 1 structures of bifas and their effects on sea urchin embryos and human cancer cells. Small molecule inhibitors and clinical trial studies. This authorea document template can be used to prepare documents according to the citation style and authoring guidelines of european journal of medicinal chemistry. Templates for the journal of medicinal chemistry are available below for articles and brief articles. European journal of medicinal chemistry xxx 2011 1e14 please cite this article in press as. Short communications are shorter pieces of work and report limited studies of the same level as. Medicinal chemistry research mcre publishes papers on a wide range of topics, favoring research with significant, new, and uptodate information. European journal of medicinal chemistry vol 85, pages 1.
Key laboratory of medicinal chemistry for natural resources, ministry of education and yunnan province, school of chemical science and technology, state key laboratory for conservation and utilization of bio. European journal of medicinal chemistry vol 185, 1. The lack of substratebound crystal structures of sirt1 and sirt2 complicates the drug design for these targets. Volume 199 in progress 1 august 2020 this issue is in progress but contains articles that are final and fully citable.
European journal of medicinal chemistry 87 2014 834e842. European journal of medicinal chemistry vol 193, 1 may 2020. Corrigendum to exploration of novel pyrrolo2,1f1,2,4triazine derivatives with improved anticancer efficacy as dual inhibitors of cmetvegfr2 european journal of medicinal chemistry 158 2018 814831. Interest in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led to their extensive investigation. European journal of medicinal chemistry 101 2015 3e325 315. A number of toxicophores have already been identified in the literature. Guide for authors european journal of medicinal chemistry. European journal of medicinal chemistry template authorea. European journal of medicinal chemistry 76 2014 79e86. European journal of medicinal chemistry vol 199, in. The most downloaded articles from european journal of medicinal chemistry in the last 90 days. European journal of medicinal chemistry 45 2010 222140.
European journal of medicinal chemistry 101 2015 3e325. It is the aim of jddmc to capture significant research related to drug designingmodeling that highlights new concepts, insight and new findings within the scope of. The backbone of the nterminal domain comprises of eightstranded bsheets, atp. European journal of medicinal chemistry 87 2014 834e842 seventy derivatives of dha 2, introducing a hydrophilic residue amino, carbamoyl, carbamate, ureide, sulfonyl, or sulfamoyl onto. Novel alkylphospholipiddtc hybrids as promising agents against endocrine related cancers acting via modulation of aktpathway, european journal of medicinal chemistry 2014, doi. Get article recommendations from acs based on references in your mendeley library. It was established in 1966 as chimica therapeutica coden.
International journal of pharmacy and chemistry science. Mutagenicity is one of the numerous adverse properties of a compound that hampers its potential to become a marketable drug. European journal of medicinal chemistry 122 2016 232e246 233 displaying the most promising activity ic 50. European journal of medicinal chemistry request pdf. Corrigendum to exploration of novel pyrrolo2,1f1,2,4triazine derivatives with improved anticancer efficacy as dual inhibitors of cmetvegfr2 european journal of medicinal chemistry. European journal of medicinal chemistry vol 185, 1 january. European journal of medicinal chemistry 62 20 352e370 353. European journal of medicinal chemistry xxx 2017 1e16 please cite this article in press as. Spectroscopic characterization of compounds based on the structure, the compounds were divided into four groups.
European journal of medicinal chemistry 70 20 758e767 763 of s 10 of 0. Medicinal chemistry research submission guidelines. European journal of medicinal chemistry 127 2017 200e209. Medicinal chemistry campaigns for the discovery of tam inhibitor 14 and related compounds by wang and coworkers. European journal of medicinal chemistry xxx 2017 1e16 3 please cite this article in press as. It is published on behalf of chempubsoc europe, a consortium of european chemical societies. Finally, structure elucidation and detailed docking studies have been carried out for the one of the most potent synthetic analog 12b. European journal of medicinal chemistry 46 2011 979e992 consists of the envelope protein, gp120 and gp41, embedded in a lipid bilayer. European journal of medicinal chemistry 116 2016 126e5. These absorption bands can be attributed to the benzenoid transition 51. Sulfurnitrogen and carbonnitrogen bond formation by. The european journal of medicinal chemistry is a global journal that publishes studies on all aspects of medicinal chemistry.
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